The Clinical Significance of Specialized Intestinal Metaplasia in the Diagnosis of Barrett's Esophagus: Nationwide Prospective Multicenter Study.
- Author:
Hyun Kyung PARK
1
;
Nayoung KIM
;
Byoung Hwan LEE
;
Jin Il KIM
;
So Young LEE
;
Hyun Min CHA
;
Hyerang KIM
;
Soo Hyun PARK
;
Jong Jae PARK
;
Sang Woo LEE
;
Ki Nam SHIM
;
Seong Eun KIM
;
Su Jin HONG
;
Il Kwun CHUNG
;
Gwang Ho BAIK
;
Hyun Soo KIM
;
Sungkook KIM
;
Jae Kyu SEONG
;
Geom Seog SEO
;
Sam Ryong JEE
;
Jeong Seop MOON
;
Mee Yon CHO
;
Jae Woo KIM
;
Moon Gi CHUNG
;
Seon Mee PARK
;
Byung Kyu NAH
;
Su Youn NAM
;
Kang Seok SEO
;
Byung Sung KO
;
Yun Ju JO
;
Jae Young JANG
;
Byeong Gwan KIM
;
Ji Won KIM
;
Kyung Sik PARK
;
Hyun Shin PARK
;
Young Sun KIM
;
Seon Hee LIM
;
Chung Hyeon KIM
;
Min Jung PARK
;
Jeong Yoon YIM
;
Kyung Ran CHO
;
Donghee KIM
;
Seun Ja PARK
;
Geun Am SONG
;
Hyun Jin KIM
;
Sang Wook KIM
;
Eui Hyeog IM
;
Kyoung Soo LEE
;
Dong Hyo HYUN
;
Hyun Young KIM
;
Sun Mi KIM
;
Jeong Eun SHIN
;
Chan Guk PARK
;
Chang Hun YANG
;
Soo Heon PARK
;
Hyun Chae JUNG
;
In Sik CHUNG
Author Information
- Publication Type:Multicenter Study ; Original Article
- Keywords: Barrett esophagus; Metaplasia; Gastroesophageal reflux
- MeSH: Barrett Esophagus; Biopsy; Chest Pain; Cough; Esophagus; Gastroesophageal Reflux; Heartburn; Hoarseness; Light; Metaplasia; Microscopy; Prospective Studies; Proton Pumps; Sensation
- From:The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2012;12(3):171-177
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND/AIMS: The meaning of specialized intestinal metaplasia (SIM) in the diagnosis of Barrett's esophagus (BE) is not clear. This study was designed to determine the clinical significance of SIM in the diagnosis of Barrett's esophagus. MATERIALS AND METHODS: Biopsies were taken from 601 subjects with endoscopically suspected columnar-lined esophagus. Under light microscopy with Alcian-blue stain, SIM was identified. Demographic characteristics, gastroesophageal (GE) reflux symptoms and endoscopic findings were compared between the SIM-present group and the SIM-absent group. RESULTS: Among 601 subjects, 184 (30.6%) were confirmed by pathology to have SIM. Age over 40 years (P<0.001) and a medication history of proton pump inhibitor or H2 blocker were found more frequently in the SIM-present group (P=0.01) than in the SIM-absent group. Any of 7 GE reflux symptoms (heartburn, acid regurgitation, chest pain, hoarseness, globus sensation, cough and epigastric soreness) were more frequent in the SIM-present group than SIM-absent group (P<0.001). Specifically, heartburn, chest pain and cough were significantly more common in the SIM-present group. There was no clinically significant difference associated with endoscopic findings or other clinical characteristics. CONCLUSIONS: When subjects with endoscopically suspected BE are analyzed based on the presence or absence of SIM, the SIM-present group was significantly associated with GE reflux symptoms suggestive of frequent GE reflux. However, the presence of SIM did not correlate with endoscopic findings.
