A Case of Leukoderma Punctata after Topical PUVA Therapy in Segmental Vitiligo Patient.
- Author:
Hyun Jeong SONG
1
;
Soo Jung PARK
;
Chang Wook KIM
;
Kyu Suk LEE
;
Sang Lip CHUNG
Author Information
1. Department of Dermatology, Keimyung University School of Medicine, Daegu, Korea. dermasong@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Leukoderma punctata;
PUVA;
Vitiligo
- MeSH:
Child;
Female;
Ficusin;
Humans;
Melanins;
Melanocytes;
Photochemotherapy;
PUVA Therapy*;
Ultraviolet Rays;
Vitiligo*
- From:Korean Journal of Dermatology
2006;44(2):190-192
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Leukoderma punctata is a rare side effect of photochemotherapy such as psoralen with solar ultraviolet light (PUVASOL) or psoralen with ultraviolet A (PUVA), and manifests as numerous discrete punctate, hypopigmented and achromic spots. Histopathologically, a focal reduction of melanocytes and melanin granules are found in the depigmented macules, revealed by S-100 and Fontana-Masson staining. The phototoxic effect of photochemotherapy on melanocytes has been suggested as the most likely cause. This occurs mostly after systemic psoralen on photochemotherapy. However, a case following topical PUVA therapy is very rare. We report a rare case of leukoderma punctata in a 6-year-old female after topical PUVA therapy for segmental vitiligo.
