Correlation between Clinicomorphologic Findings and Clinical Outcome in Childhood Henoch-Schonlein Purpura Nephritis.
- Author:
Yun Jung HUH
1
;
Jae IL SHIN
;
Jee Min PARK
;
Jae Seung LEE
;
Hyeon Joo JEONG
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. jsyonse@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Henoch-Schonlein purpura nephritis;
Pathology;
Prognosis
- MeSH:
Child;
Female;
Hematuria;
Humans;
Male;
Nephritis*;
Nephrotic Syndrome;
Pathology;
Prognosis;
Purpura, Schoenlein-Henoch*
- From:Journal of the Korean Society of Pediatric Nephrology
2003;7(1):30-37
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Henoch-Schonlein purpura(HSP) is usually a self-limited disease with a good eventual outcome. The prognosis of HSP is mainly determined by the renal involvement. In this study, We evaluated children with biopsy-proven Henoch-Schonlein purpura nephritis about the clinical outcome correlated with renal manifestation and morphologic findings. METHODS: The clinical features, initial laboratory and pathologic findings, and clinical outcome were evaluated in 60 children with biopsy-proven Henoch-Schonlein purpura nephritis at Yonsei University Severance Hospital during the period from Jan. 1990 to Dec. 2002. RESULTS: The ratio of male to female patients was 1.2:1. The interval between the onset of Henoch-Schonlein purpura and renal manifestation was less than 3 months in 81% of the patients. Initial renal manifestation was microscopic hematuria in 100% of patients, isolated hematuria in 15%, acute nephritic syndrome in 7%, nephrotic syndrome in 22% of patients. Renal manifestation correlated with clinical outcome. Grade II and III were the most common in histologic grades of ISKDC. Renal pathologic finding correlated with clinical outcome. CONCLUSION: Renal manifestation and pathologic findings correlated with the clinical outcome. It is necessary to evaluate the correlation between pathologic findings and treatment.
