Pubertal growth and epiphyseal fusion.
- Author:
Kye Shik SHIM
1
Author Information
- Publication Type:Review
- Keywords: Growth; Puberty; Growth plate
- MeSH: Adolescent; Axis; Bone Development; Chondrocytes; Estrogens; Growth Plate; Humans; Puberty
- From:Annals of Pediatric Endocrinology & Metabolism 2015;20(1):8-12
- CountryRepublic of Korea
- Language:English
- Abstract: The complex networks of nutritional, cellular, paracrine, and endocrine factors are closely related with pubertal growth and epiphyseal fusion. Important influencing factors include chondrocyte differentiation capacity, multiple molecular pathways active in the growth plate, and growth hormone-insulin-like growth factor-I axis activation and epiphyseal fusion through estrogen and its receptors. However, the exact mechanisms of these phenomena are still unclear. A better understanding of the detailed processes involved in the pubertal growth spurt and growth plate closure in longitudinal bone growth will help us develop methods to efficiently promote pubertal growth and delay epiphyseal fusion with fewer adverse effects.
