Allergy Inhibition Using Naturally Occurring Compounds Targeting Thymic Stromal Lymphopoietin Pathways: a Comprehensive Review
10.4062/biomolther.2024.177
- Author:
Le Ba VINH
1
;
Kyeong Seon LEE
;
Yoo Kyong HAN
;
Young Jun KIM
;
Suzy KIM
;
Abdul Bari SHAH
;
Youngjoo BYUN
;
Ki Yong LEE
Author Information
1. College of Pharmacy, Korea University, Sejong 30019, Republic of Korea
- Publication Type:Review
- From:Biomolecules & Therapeutics
2025;33(2):249-267
- CountryRepublic of Korea
- Language:English
-
Abstract:
Naturally occurring compounds have widely been applied to treat diverse pharmacological effects, including asthma, allergic diseases, antioxidants, inflammation, antibiotics, and cancer. Recent research has revealed the essential role of the thymic stromal lymphopoietin (TSLP) in regulating inflammatory responses at mucosal barriers and maintaining immune homeostasis. Asthma, inflammation, and chronic obstructive pulmonary disease are allergic disorders in which TSLP plays a significant role. Although TSLP’s role in type 2 immune responses has undergone comprehensive investigation, its involvement in inflammatory diseases and cancer has also been found to be expanding. However, investigating how to block the TSLP pathway using natural products has been limited. This paper summarizes the roles of various medicinal plants and their chemical components that effectively inhibit the TSLP pathway. In addition, we also highlight the contributions of several plant-derived compounds to treat allergic diseases via targeting TSLP. This review intends to offer innovative concepts to scientists investigating the use of naturally produced compounds and extracts for the treatment of allergic illnesses.
