Clinical Trial on the Hypertensive Effect of Bunazosin.
10.4070/kcj.1988.18.4.719
- Author:
Ki Young OH
;
Kyung Soo KIM
;
Jeong Hyun KIM
;
Heon Kil LIM
;
Bang Hun LEE
;
Chung Kyun LEE
- Publication Type:Clinical Trial ; Original Article
- MeSH:
Blood Cell Count;
Blood Pressure;
Blood Urea Nitrogen;
Cholesterol;
Creatinine;
Heart Rate;
Humans;
Hypertension
- From:Korean Circulation Journal
1988;18(4):719-724
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The clinical trial was carried out with Bunazosin in 31 patients with essential hypertension. The results were as follows : 1) Before and after 1, 2, 4, 6, and 8 weeks of medications, the overall average systolic and distolic blood pressure were 166.5+/-21.8/105.7+/-10.6, 152.7+/-17.2/99.8+/-11.1, 149.5+/-18.1/98.4+/-11.7, 148.5+/-16.9/97.3+/-11.3, 148.5+/-16.7/95.6+/-10.9 and 144.0+/-14.9/94.2+/-11.1mmHg. As a result, blood pressure significantly fell within 1week of medication, and marked and moderate degree of hypetensive effect was observed within 8weeks og medication in 45% of all cases. 2) Before and after 1, 2, 4, 6, and 8weeks of medication, the overall average heart rates were 79.7+/-10.1, 78.3+/-9.1, 79.4+/-7.4, 80.8+/-8.3, 79.2+/-8.9 and 80.1+/-8.3 beats/minute. There were no significant change in heart rates before and after medication. 3) There were no significant changes in values of complete blood counts, GOT, GDT, blood urea nitrogen, serum creatinine and total cholesterol before and after medication. On the basis of these results, we observed that Bunazosin was effective hypertensive drug.
