Influence of vaccine potency and booster administration of foot-and-mouth disease vaccines on the antibody response in calves with maternal antibodies.
10.4142/jvs.2017.18.S1.315
- Author:
Can ÇOKÇALIŞKAN
1
;
Tunçer TÜRKOĞLU
;
Ergün UZUNLU
;
Beyhan SAREYYÜPOĞLU
;
Ibrahim HANCI
;
Ahmet İPEK
;
Abdullah ARSLAN
;
Ayca BABAK
;
Gülnur İLDENIZ
;
Veli GÜLYAZ
Author Information
1. Institute of Foot and Mouth Disease (SAP), Ministry of Food, Agriculture and Livestock, Ankara 06044, Turkey. cancokcaliskan@gmail.com
- Publication Type:Original Article
- Keywords:
calf;
foot-and-mouth disease;
high potency vaccine;
maternal antibody;
virus neutralization
- MeSH:
Agriculture;
Animals;
Antibodies*;
Antibodies, Neutralizing;
Antibody Formation*;
Foot-and-Mouth Disease*;
Mass Vaccination;
Methods;
Neutralization Tests;
Vaccination;
Vaccine Potency*;
Vaccines*;
Virus Diseases
- From:Journal of Veterinary Science
2017;18(S1):315-322
- CountryRepublic of Korea
- Language:English
-
Abstract:
Foot-and-mouth disease is one of the most important viral diseases of cloven-hoofed animals. Mass vaccination is an effective method to control the disease and is frequently utilized in endemic regions. Sufficient protection of young animals is important in mass vaccination campaigns. Maternal antibodies negatively affect the success of vaccination. Hence, determination of the optimal vaccination age is crucial for the uninterrupted protection of young animals. This study was performed to identify the effect of vaccine potency and booster administration on serum neutralizing antibody titers of calves with different levels of maternal antibodies. Calves (n = 111) on a state farm were used in this study. Oil adjuvant foot-and-mouth disease vaccines with 3 PD₅₀ and 6 PD₅₀ potencies were used with or without booster administration. Serum samples were collected each month up to day 120 postvaccination. Virus neutralization tests were used to measure the serum neutralizing antibody titers and estimate the protection period by using pre-determined cut-off values for protection. The results revealed that a vaccination with a 6 PD₅₀ potency vaccine, preferably followed by a booster dose, should be used to overcome maternal immunity for incessant protection.
