Evaluation on the early alterations in retinal and choroidal microvascular and microstructural characteristics of systemic lupus erythematosus patients via ultra-widefield swept-source optical coherence tomography angiography
10.3980/j.issn.1672-5123.2025.7.18
- VernacularTitle:UWF SS-OCTA评估系统性红斑狼疮患者视网膜和脉络膜微血管及微结构的早期变化特征
- Author:
Yingyi ZHAO
1
;
Xinshu LIU
1
;
Cancan SHI
1
;
Mingxin LI
1
;
Jili CHEN
1
;
He WANG
1
Author Information
1. Graduate School of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
ultra-widefield swept-source optical coherence tomography angiography(UWF SS-OCTA);
systemic lupus erythematosus;
retina;
choroid
- From:
International Eye Science
2025;25(7):1140-1146
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To quantitatively assess the early alterations of retinal and choroidal microcirculation and microstructure in systemic lupus erythematosus(SLE)patients without coexisting retinopathy via ultra-widefield swept-source optical coherence tomography angiography(UWF SS-OCTA).METHODS:Cross-sectional study. Totally 64 cases(64 eyes)that diagnosed as SLE without associated retinopathy at the Affiliated Hospital of Xuzhou Medical University from May to October 2024 were enrolled as the study group(Randomly assign one eye to the study group). Simultaneously, age-and gender-matched healthy individuals were recruited as the control group. All participants underwent UWF SS-OCTA. The deep capillary plexus(DCP), superficial capillary plexus(SCP), total retina, choriocapillaris(CC), as well as the choroidal medium and large vessel density(VD)in both the central and peripheral retinal areas of both groups of patients were compared. Additionally, parameters such as choroidal vascularity volume(CVV), choroidal vascularity index(CVI), thickness of the inner retina, outer retina, entire retina, and choroid in both central and peripheral area. SLE patients were categorized into three subgroups based on the SLE disease activity index(SLEDAI-2K), including 20 cases(20 eyes)in mild-and no-activity group(SLEDAI-2K≤6), 20 cases(20 eyes)in moderate-activity group(7
