Protective effect of vascular endothelial growth factor B on retinal nerve cells
10.3980/j.issn.1672-5123.2025.7.09
- VernacularTitle:血管内皮生长因子-B对视网膜神经细胞的保护作用
- Author:
Xin SUN
1
;
Lei ZHANG
1
;
Honglian GAO
1
;
Shoukuan ZHANG
1
;
Jun JIANG
1
Author Information
1. Department of Ophthalmology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor-B;
retinal neuronal cells;
apoptosis;
anti-oxidation
- From:
International Eye Science
2025;25(7):1089-1093
- CountryChina
- Language:Chinese
-
Abstract:
The retina has a complex and delicate function and structure, containing a large number of neuronal cells with extremely limited regenerative capacity, which are susceptible to damage and apoptosis under pathological conditions such as ischemia and hypoxia, resulting in irreversible vision loss. Retinal diseases are very common, such as retinitis pigmentosa(RP), age-related macular degeneration(ARMD), diabetic retinopathy(DR), and glaucoma. Most of the diseases in this category are treated symptomatically, which is effective but has some limitations in neuroprotection. Vascular endothelial growth factor(VEGF)-B is functionally relatively inert in the VEGF family, and unlike pro-angiogenic VEGF-A, VEGF-B shows functional inertia in angiogenesis but exhibits significant neuroprotective effects. VEGF-B is a potent anti-apoptotic, antioxidant factor that can regulate the expression of apoptotic genes and enhance the expression of glutamic acid decarboxylase 1 by binding to VEGFR-1 to activate the ERK1/2 or Akt pathway, in addition to decreasing the expression of glutamate, resulting in retinal neuroprotective effects. In this article, the protective effects of VEGF-B on retinal neuronal cells were reviewed to provide new ideas for the treatment of retina-associated diseases.
