The role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in liver diseases
- VernacularTitle:3-羟基-3-甲基戊二酰辅酶A还原酶（HMGCR）在肝脏疾病中的作用
- Author:
Yangling ZENG
1
;
Yunyong WANG
1
;
Haimei GUAN
1
;
Tianwen WANG
1
;
Baohua XIE
1
;
Guobao LI
1
;
Riyun ZHANG
1
;
Tingshuai WANG
2
;
Dewen MAO
2
Author Information
- Publication Type:Review
- Keywords: Liver Diseases; 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase; Cholesterol
- From: Journal of Clinical Hepatology 2025;41(5):983-990
- CountryChina
- Language:Chinese
- Abstract: Cholesterol is an essential molecule for the biosynthesis of cell membranes and cell proliferation and differentiation， and the liver plays a central role in cholesterol metabolism and is responsible for the synthesis， uptake， secretion， and transport of cholesterol. The initial stages of cholesterol synthesis in the liver are particularly important， and abnormalities in such stages are closely associated with the progression of various liver diseases. Studies have shown that as a key rate-limiting enzyme in cholesterol biosynthesis， 3-hydroxy-3-methylglutaryl-coenzyme A reductase （HMGCR） has well-defined regulatory properties and has been confirmed as an important target for the regulation of various liver diseases. This article reviews the process of cholesterol metabolism， the degradation and regulatory mechanisms of HMGCR， and the application of inhibitors， as well as the role of HMGCR in liver diseases， in order to provide new insights for scientific research and the clinical prevention and treatment of liver diseases.
