Role of ubiquitin-specific proteases in hepatocellular carcinoma
- VernacularTitle:泛素特异性蛋白酶在肝细胞癌中的作用
- Author:
Yi TANG
1
;
Guotai WANG
2
;
Yuhan JIANG
1
Author Information
- Publication Type:Review
- Keywords: Carcinoma， Hepatocellular; Ubiquitin-Specific Proteases; Enzyme Inhibitors
- From: Journal of Clinical Hepatology 2025;41(5):968-974
- CountryChina
- Language:Chinese
- Abstract: Hepatocellular carcinoma （HCC） is a common primary malignant tumor. In recent years， the role of ubiquitin-specific proteases （USPs） in HCC has attracted widespread attention. USPs are a class of key deubiquitinating enzymes that affect a variety of biological processes by regulating the ubiquitination status of proteins. Studies have shown that USPs participate in the regulation of cell proliferation， apoptosis， migration， and invasion by deubiquitinating various tumor-related proteins. In addition， the abnormal expression of USPs is closely associated with the prognosis of HCC patients and may thus be used as potential biomarkers and therapeutic targets. This article reviews the research advances in USPs in HCC and explores their key roles in the development， progression， and metastasis of HCC. A deep understanding of the mechanism of action of USPs in HCC not only helps to reveal the pathogenesis of HCC， but also provides a scientific basis for developing new diagnostic tools and treatment strategies. Future research should further explore the regulatory effect of USPs in HCC， in order to provide more effective means for the clinical treatment of HCC.
