Immunomodulatory effect of short-chain fatty acids in hepatic encephalopathy and its potential diagnostic value
- VernacularTitle:短链脂肪酸在肝性脑病中的免疫调节作用及潜在诊疗价值
- Author:
Weiyu CHEN
1
;
Dewen MAO
2
;
Han WANG
2
;
Yang DU
1
;
Wenqian FENG
1
;
Lei FU
3
;
Chun YAO
3
Author Information
- Publication Type:Review
- Keywords: Hepatic Encephalopathy; Fatty Acids， Volatile; Immunomodulation; Gastrointestinal Microbiome
- From: Journal of Clinical Hepatology 2025;41(5):954-962
- CountryChina
- Language:Chinese
- Abstract: Hepatic encephalopathy （HE） is a common complication of severe liver disease in the end stage， and it is urgently needed to improve the rate of effective treatment and clarify the pathogenesis of HE. The liver is a crucial hub for immune regulation， and disruption of immune homeostasis is a key factor in the pathological mechanisms of HE. As the main metabolites of intestinal flora， short-chain fatty acids （SCFAs） play a vital role in the biological processes of both innate and adaptive immunity and can regulate the proliferation and differentiation of immune cells maintain the homeostasis of intestinal microenvironment and the integrity of barrier function. Studies have shown that SCFAs participate in bidirectional and dynamic interactions with the liver-gut-brain axis through immunomodulatory pathways， thereby playing an important role in the diagnosis， treatment， and prognostic evaluation of HE. Starting from the immunoregulatory effect of SCFAs， this article summarizes and analyzes the crosstalk relationship between SCFAs and the liver-gut-brain axis and the significance of SCFAs in the diagnosis and treatment of HE， in order to provide new ideas for optimizing clinical prevention and treatment strategies.
