Study on pharmacokinetic characteristics of ciprofol in pregnant and fetal rats
- VernacularTitle:环泊酚在孕鼠与胎鼠体内的药动学特征研究
- Author:
Wenhao CHU
1
;
Yuanman QIN
1
;
Tiantian ZHANG
1
;
Jiaqi XU
2
;
Ying LI
1
;
Zhiqing ZHANG
1
Author Information
1. Dept. of Pharmacy，the Second Hospital of Hebei Medical University，Shijiazhuang 050000，China
2. School of Pharmacy，Hebei Medical University，Shijiazhuang 050011，China
- Publication Type:Journal Article
- Keywords:
ciprofol;
pregnant rats;
fetal rats;
placental barrier;
pharmacokinetics;
blood concentration
- From:
China Pharmacy
2025;36(11):1348-1351
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the pharmacokinetic characteristics of ciprofol in pregnant and fetal rats， and provide reference for the application of ciprofol in cesarean section. METHODS Eight pregnant rats were selected. A single dose of 2.4 mg/kg of ciprofol was administered via the tail vein. One fetal rat was selected at 2， 4， 8， 12， 16， 25， 35， 45， 60， and 90 minutes respectively after ciprofol administration. Subsequently， whole blood samples were collected simultaneously from both the pregnant rats and fetal rats. HPLC-MS/MS method was used to determine the concentration of ciprofol in the bodies of pregnant and fetal rats. The ratios of fetal-to-maternal blood concentrations （F/M ratios） at each time point were calculated， and the F/M-time curves were plotted. Subsequently， non-compartmental pharmacokinetic parameters were computed using DAS 2.0 software. RESULTS Compared with pregnant rats， cmax， AUC0-90 min and AUC0-∞ of ciprofol in fetal rats were decreased significantly， while MRT was increased significantly （P＜0.05）. The F/M curve of ciprofol initially increased and then decreased， and between 0.16- 0.84， reaching a maximum value of 0.84 at 45 minutes. CONCLUSIONS Ciprofol can penetrate the placental barrier， and there are significant differences in pharmacokinetic parameters between pregnant and fetal rats. Moreover， the exposure level of ciprofol in fetal rats is much lower than that in pregnant rats. Therefore， ciprofol shows promise as an ideal anesthetic agent for cesarean section delivery.
