Clinical Features and Radiological Findings of Adenovirus Pneumonia Associated with Progression to Acute Respiratory Distress Syndrome: A Single Center Study in 19 Adult Patients.
10.3348/kjr.2016.17.6.940
- Author:
Min Jae CHA
1
;
Myung Jin CHUNG
;
Kyung Soo LEE
;
Tae Jung KIM
;
Tae Sung KIM
;
Semin CHONG
;
Jungho HAN
Author Information
1. Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06973, Korea.
- Publication Type:Original Article
- Keywords:
Adenovirus;
Pneumonia;
Acute respiratory distress syndrome;
Chest radiograph;
CT
- MeSH:
Adenoviridae*;
Adult*;
Consensus;
Humans;
Mortality;
Pleural Effusion;
Pneumonia*;
Radiography, Thoracic;
Respiratory Distress Syndrome, Adult*;
Tertiary Care Centers;
Tertiary Healthcare
- From:Korean Journal of Radiology
2016;17(6):940-949
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To describe radiologic findings of adenovirus pneumonia and to understand clinico-radiological features associated with progression to acute respiratory distress syndrome (ARDS) in patients with adenovirus pneumonia. MATERIALS AND METHODS: This study included 19 patients diagnosed with adenovirus pneumonia at a tertiary referral center, in the period between March 2003 and April 2015. Clinical findings were reviewed, and two radiologists assessed imaging findings by consensus. Chi-square, Fisher's exact, and Student's t tests were used for comparing patients with and without subsequent development of ARDS. RESULTS: Of 19 patients, nine were immunocompromised, and 10 were immunocompetent. Twelve patients (63%) progressed to ARDS, six of whom (32%) eventually died from the disease. The average time for progression to ARDS from symptom onset was 9.6 days. Initial chest radiographic findings were normal (n = 2), focal opacity (n = 9), or multifocal or diffuse opacity (n = 8). Computed tomography (CT) findings included bilateral (n = 17) or unilateral (n = 2) ground-glass opacity with consolidation (n = 14) or pleural effusion (n = 11). Patients having subsequent ARDS had a higher probability of pleural effusion and a higher total CT extent compared with the non-ARDS group (p = 0.010 and 0.007, respectively). However, there were no significant differences in clinical variables such as patient age and premorbid condition. CONCLUSION: Adenovirus pneumonia demonstrates high rates of ARDS and mortality, regardless of patient age and premorbid conditions, in the tertiary care setting. Large disease extent and presence of pleural effusion on CT are factors suggestive of progression to ARDS.
