Short-course palliative radiotherapy for uterine cervical cancer.
10.3857/roj.2013.31.4.216
- Author:
Dong Hyun KIM
1
;
Ju Hye LEE
;
Yong Kan KI
;
Ji Ho NAM
;
Won Taek KIM
;
Ho Sang JEON
;
Dahl PARK
;
Dong Won KIM
Author Information
1. Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea. dongwk51@hanmail.net
- Publication Type:Original Article
- Keywords:
Cervix uteri;
Carcinoma;
Palliation;
Hypofractionation;
Radiotherapy
- MeSH:
Cervix Uteri;
Diarrhea;
Female;
Follow-Up Studies;
Humans;
Palliative Care;
Pelvic Pain;
Radiotherapy*;
Radiotherapy, Conformal;
Retrospective Studies;
Uterine Cervical Neoplasms*;
Uterine Hemorrhage
- From:Radiation Oncology Journal
2013;31(4):216-221
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of this retrospective study was to evaluate the efficacy and feasibility of short-course hypofractionated radiotherapy (RT) for the palliation of uterine cervical cancer. MATERIALS AND METHODS: Seventeen patients with cancer of the uterine cervix, who underwent palliative hypofractionated 3-dimensional conformal radiotherapy between January 2002 and June 2012, were retrospectively analyzed. RT was delivered to symptomatic lesions (both the primary mass and/or metastatic regional lymph nodes). The total dose was 20 to 25 Gy (median, 25 Gy) in 5 Gy daily fractions. RESULTS: The median follow-up duration was 12.2 months (range, 4 to 24 months). The median survival time was 7.8 months (range, 4 to 24 months). Vaginal bleeding was the most common presenting symptom followed by pelvic pain (9 patients). The overall response rates were 93.8% and 66.7% for vaginal bleeding control and pelvic pain, respectively. Nine patients did not have any acute side effects and 7 patients showed minor gastrointestinal toxicity. Only 1 patient had grade 3 diarrhea 1 week after completion of treatment, which was successfully treated conservatively. Late complications occurred in 4 patients; however, none of these were of grade 3 or higher severity. CONCLUSION: Short-course hypofractionated RT was effective and well tolerated as palliative treatment for uterine cervical cancer.
