A Case of Multiple Cranial Neuropathies Caused by Anaplastic Lymphoma Kinase-Negative Anaplastic Large Cell Lymphoma
10.3342/kjorl-hns.2024.00241
- Author:
Hyeop OH
1
;
Su Mi SEONG
;
Eo Jin KIM
;
Bo Hae KIM
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea
- Publication Type:Case Report
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2025;68(3):121-126
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multiple cranial neuropathies (MCN) can be caused by various etiologies, such as autoimmune diseases, neurovascular diseases, tumors, or infections. Among the various etiologies of MCN, malignant lymphoma is a major cause. Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK-ALCL) is an extremely rare subtype of T-cell lymphoma that exhibits aggressive behavior, particularly when affecting the central nervous system (CNS). The rarity of ALK-ALCL often leads to a relative delay in diagnosis compared to other types of lymphoma. We experienced a patient with MCN, for whom malignant lymphoma was suspected and diagnosed with ALK-ALCL, which simultaneously involved multiple cranial nerves, bilateral submandibular glands (SMGs), and the stomach within a relatively short time. Herein, we report our diagnostic experience of ALK-ALCL, along with a literature review.
