Small GTPases and formins in mammalian oocyte maturation: cytoskeletal organizers.
- Author:
Sojung KWON
1
;
Hyunjung J LIM
Author Information
- Publication Type:Review
- Keywords: Oocyte; Spindle; Formin; GTP Phosphohydrolases; Human; Mice
- MeSH: Actin Cytoskeleton; Animals; Asymmetric Cell Division; Cytoskeleton; GTP Phosphohydrolases; Humans; Mice; Microtubules; Monomeric GTP-Binding Proteins; Nerve Tissue Proteins; Oocytes; Proteins
- From:Clinical and Experimental Reproductive Medicine 2011;38(1):1-5
- CountryRepublic of Korea
- Language:English
- Abstract: The maturation process of mammalian oocytes accompanies an extensive rearrangement of the cytoskeleton and associated proteins. As this process requires a delicate interplay between the cytoskeleton and its regulators, it is often targeted by various external and internal adversaries that affect the congression and/or segregation of chromosomes. Asymmetric cell division in oocytes also requires specific regulators of the cytoskeleton, including formin-2 and small GTPases. Recent literature providing clues regarding how actin filaments and microtubules interact during spindle migration in mouse oocytes are highlighted in this review.
