Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility.
- Author:
Sun Hee LEE
1
;
Suman LEE
Author Information
- Publication Type:Original Article
- Keywords: Kallikrein-related Peptidase 2; Polymorphism, Single Nucleotide; Infertility, Male; Human
- MeSH: Alleles; Genetic Association Studies; Genotype; Humans; Infertility, Male; Introns; Male; Odds Ratio; Polymorphism, Single Nucleotide; Semen
- From:Clinical and Experimental Reproductive Medicine 2011;38(1):6-9
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility. METHODS: We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping. RESULTS: The SNP of the KLK2 gene had a statistically significant association with male infertility (p<0.05). The odds ratio for the minor allele (+255A) in the pooled sample was 0.47 (95% confidence intervals, 0.26-0.85) for rs2664155. CONCLUSION: The relationship of KLK2 SNP to male infertility is statistically significant, especially within the non-azoospermia group. Further study is needed to understand the mechanisms associated with male infertility.
