Sarcoidosis with a Necrotizing Sarcoid Granulomatosis Pattern Presenting as Persistent Low-Grade Fever:A Case Report
- Author:
Se Ri KANG
1
;
Keum Ha CHOI
;
Ji Young RHO
Author Information
- Publication Type:Case Report
- From: Journal of the Korean Society of Radiology 2024;85(5):948-953
- CountryRepublic of Korea
- Language:English
- Abstract: Necrotizing sarcoid granulomatosis (NSG), now referred to as “sarcoidosis with NSG pattern,” is an uncommon variant of sarcoidosis. NSG is characterized by a trio of features: sarcoid granulomas, vasculitis, and extensive areas of necrosis. Symptoms can include cough, fever, chest pain, and dyspnea, typically presenting as either solitary or multiple lung nodules or masses. In this report, we describe a case of NSG accompanied by a persistent low-grade fever. Unlike the dominant presentation of NSG with single or multiple nodules, our case demonstrated diffuse micronodules with combined perilymphatic and random distribution on CT.Histological examination revealed widespread necrotizing granulomas surrounded by anthracotic pigmentation, alongside necrosis and vasculitis, diverging from the classic presentation of sarcoidosis. The diagnosis of NSG was established through a multidisciplinary discussion. The patient was administered oral prednisolone that led to noticeable clinical and radiological improvement within three months.
