Tamsulosin versus Alfuzosin in the Treatment of Patients with Distal Ureteral Stones: Prospective, Randomized, Comparative Study.
10.4111/kju.2010.51.3.193
- Author:
Abul Fotouh Abdel-Maguid AHMED
1
;
Abul Yazid Saad AL-SAYED
Author Information
1. Department of Urology, Ghodran Hospital, KSA. abulfotouhahmed@yahoo.com
- Publication Type:Comparative Study ; Original Article ; Randomized Controlled Trial
- Keywords:
Urinary calculi;
Ureter;
Alfuzosin;
Tamsulosin
- MeSH:
Diclofenac;
Follow-Up Studies;
Humans;
Prospective Studies;
Quinazolines;
Sulfonamides;
Ureter;
Urinary Calculi
- From:Korean Journal of Urology
2010;51(3):193-197
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We evaluated and compared the efficacy of tamsulosin and alfuzosin in the medical treatment of symptomatic, uncomplicated distal ureteral stones. MATERIALS AND METHODS: A total of 87 patients with distal ureteral stones of < or =10 mm were randomly divided into 3 groups. Group I patients (n=29) received 0.4 mg tamsulosin daily, group II patients (n=30) received 10 mg alfuzosin daily, and group III patients (n=28) were not given tamsulosin or alfuzosin. Patients in all groups received Diclofenac sodium regularly for 1 week and then on demand. Follow-up was done on a weekly basis for 30 days. RESULTS: The mean stone size was comparable in the 3 groups (4.97+/-2.24, 5.47+/-2.13, and 5.39+/-1.81 mm, respectively). The stone expulsion rate was 86.2%, 76.6%, and 50% in groups I, II, and III, respectively. The difference in groups I and II with respect to group III was significant (p=0.0028 and 0.035). The mean expulsion time for groups I to III was 7.52+/-7.06, 8.26+/-7.34, and 13.90+/-6.99 days, respectively. The expulsion time was significantly shorter in groups I and II than in group III (p=0.0097 and 0.026). Patients taking tamsulosin and alfuzosin had fewer pain attacks than did group III patients (1.24+/-0.57 vs. 1.43+/-0.67 vs. 1.75+/-1.17). Only 3 cases of drug side effects, 2 in group I and 1 in group II, were recorded. CONCLUSIONS: The use of tamsulosin or alfuzosin for the medical treatment of lower ureteric stones proved to be safe and effective. Moreover, tamsulosin did not have any significant benefits over alfuzosin.
