Effect of Clonidine Premedication on Isoflurane Induced Hypotensive Anesthesia.
10.4097/kjae.1992.25.6.1206
- Author:
Sung Min HAN
1
Author Information
1. Department of Anesthesiology, College of Medicine, University of Ulsan, Korea.
- Publication Type:Original Article
- Keywords:
Premedication;
Clonidine;
Induced hypotension;
Isoflurane
- MeSH:
Anesthesia*;
Clonidine*;
Diazepam;
Humans;
Hypotension;
Isoflurane*;
Nitroprusside;
Premedication*;
Spine
- From:Korean Journal of Anesthesiology
1992;25(6):1206-1211
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effect of single dose clonidine premedication on the vapour requirement for isoflurane induced hypotension in 20 patients undergoing spine surgery was evaluated. The patients given 5 ug/kg of clonidine P.O. at 90 minutes before operation required a mean expired isoflurane concentration of 1.2+/-0.5 vol% to induce hypotension compared with 2.1+/-0.6 vol% in 0.2 mg/kg of diazepam predmedication group(P<0.05). To achieve satisfactory hypotension, six out of ten patients in diazepam premedication group and l out of 10 patients in clondine premedication group are required supplementary infusion of sodium nitroprusside. In conclusion, clonidine premedication is recommended in isoflurane induced hypotensive anesthesia.
