Electrophysiologic and long-term effects of propafenone on paroxysmal supraventricular tachycardia.
10.4070/kcj.1993.23.3.440
- Author:
Yun Shik CHOI
;
Dae Won SOHN
;
Myoung Mook LEE
;
Young Bae PARK
;
Jung Don SEO
;
Young Woo LEE
- Publication Type:Original Article
- Keywords:
Propafenone;
Paroxysmal supraventricular tachycardia
- MeSH:
Atrioventricular Node;
Dyspepsia;
Follow-Up Studies;
Humans;
Propafenone*;
Tachycardia;
Tachycardia, Supraventricular*;
Wolff-Parkinson-White Syndrome
- From:Korean Circulation Journal
1993;23(3):440-447
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Propafenone is a new class IC antiarrhythmic drug that has been found to be effective in both supraventricular and ventricular tachyarrhythmias. We studied the electrophysiologic and long-term effects of oral propafenone in the patients with paroxysmal supraventricular tachycardia(PSVT). METHODS: The electrophysiologic study was done in 15 patients with PSVT to assess the short-term efficacy of propafenone 450mg daily. For 10 patients with short-term efficacy, follow up study was done to assess the long-term efficacy of propafenone 450mg daily. RESULTS: The electrophysiologic mechanisms of PSVT were AV nodal reentry in 6 patients and AV reentry in 9 patients. During the electrophysiologic study, propafenone prolonged AH, HV and PR intervals significantly(p<0.05), but did not change the corrected SNRT, SACT, and the ERP of atrium, ventricle, AV node and accessory pathway(AP) significantly. The anterograde and retrograde 1:1 conduction capacity of AV node and AP seemed to decrease. Complete block of anterograde conduction over the AP was noted in 2 of 3 patients with manifest WPW syndrome and complete block of retrograde conduction was noted over the AV node in 1 patient with AV nodal reentry and over the AP in 1 patient with AV reentry. Propafenone was effective in 3 of 6 patients with AVNRT and 7 of 9 patients with AVRT. During long term administration for 3 to 11 months in 10 patients with short-term efficacy of propafenone, 7 patients did not report any episode of symptomatic tachycardia and 3 patients reported less frequent palpitation. There were no side effects during short-and long-term follow up except 2 patients with mild indigestion. CONCLUSIONS: Propafenone seems to be a safe, well tolerated and effective drug for short and long-term therapy of patients with PSVT, especially of orthodromic AV reentry.
