Effect of terazosin on blood pressure and serum lipids in nild to moderate hypertension.
10.4070/kcj.1993.23.3.454
- Author:
Jong Pil KIM
;
In Koo KANG
;
Seung Cheol SHIM
;
Ock Chan LEE
;
Kyung Soo KIM
;
Jeong Hyun KIM
;
Heon Kil IM
;
Bang Hun LEE
;
Chung Kyun LEE
- Publication Type:Original Article
- MeSH:
Asthenia;
Blood Pressure*;
Body Weight;
Cholesterol;
Dizziness;
Edema;
Exanthema;
Headache;
Heart Rate;
Humans;
Hypertension*;
Triglycerides
- From:Korean Circulation Journal
1993;23(3):454-460
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: We evaluated the antihypertensive effect, safety and effect on serum lipids of terazosin, second generation alpha1-blocker. METHODS: Terazosin 1-4mg was adminstered once daily in 20 patients for 12 weeks with dose titration every 2 weeks. RESULTS: 1) The systolic and diastolic blood pressure were decreased from 170.0+/-13.0/104.0+/-6.0mmHg to 144.0+/-13.3/88.0+/-5.6mmHg(p<0.01), but the heart rate and body weight were independant of terazosin administration. 2) Total cholesterol was decreased significantly from 209.9+/-33.5mg/dL to 194.6+/-30.1mg/dL after 12 weeks treatment(p<0.05), triglyceride was decreased significantly from 185.4+/-37.0mg/dL to 168.9+/-35.0mg/dL(p<0.05). and LDL-cholesterol was decreased significantly from 134.5+/-31.9mg/dL to 122.7+/-29.9mg/dL(p<0.05), but HDL-cholesterol was increased significantly from 37.8+/-5.6mg/dL to 40.6+/-5.5mg/dL(p<0.05). 3) The adverse effects of terazosin were dizziness in 2, headache in 2, asthenia in 1, peripheral edema in 1 and skin rash in 1 patient, but were not troublesome enough to stop medication. CONCLUSIONS: Terazosin 1-4mg once daily regimen was effective and safe as an antihypertensive agent, and moreover terazosin has favorable effects on serum lipids.
