Long-Term Incidence of Gastrointestinal Bleeding Following Ischemic Stroke
- Author:
Jun Yup KIM
1
;
Beom Joon KIM
;
Jihoon KANG
;
Do Yeon KIM
;
Moon-Ku HAN
;
Seong-Eun KIM
;
Heeyoung LEE
;
Jong-Moo PARK
;
Kyusik KANG
;
Soo Joo LEE
;
Jae Guk KIM
;
Jae-Kwan CHA
;
Dae-Hyun KIM
;
Tai Hwan PARK
;
Kyungbok LEE
;
Hong-Kyun PARK
;
Yong-Jin CHO
;
Keun-Sik HONG
;
Kang-Ho CHOI
;
Joon-Tae KIM
;
Dong-Eog KIM
;
Jay Chol CHOI
;
Mi-Sun OH
;
Kyung-Ho YU
;
Byung-Chul LEE
;
Kwang-Yeol PARK
;
Ji Sung LEE
;
Sujung JANG
;
Jae Eun CHAE
;
Juneyoung LEE
;
Min-Surk KYE
;
Philip B. GORELICK
;
Hee-Joon BAE
;
Author Information
- Publication Type:Original Article
- From:Journal of Stroke 2025;27(1):102-112
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:and Purpose Previous research on patients with acute ischemic stroke (AIS) has shown a 0.5% incidence of major gastrointestinal bleeding (GIB) requiring blood transfusion during hospitalization. The existing literature has insufficiently explored the long-term incidence in this population despite the decremental impact of GIB on stroke outcomes.
Methods:We analyzed the data from a cohort of patients with AIS admitted to 14 hospitals as part of a nationwide multicenter prospective stroke registry between 2011 and 2013. These patients were followed up for up to 6 years. The occurrence of major GIB events, defined as GIB necessitating at least two units of blood transfusion, was tracked using the National Health Insurance Service claims data.
Results:Among 10,818 patients with AIS (male, 59%; mean age, 68±13 years), 947 (8.8%) experienced 1,224 episodes of major GIB over a median follow-up duration of 3.1 years. Remarkably, 20% of 947 patients experienced multiple episodes of major GIB. The incidence peaked in the first month after AIS, reaching 19.2 per 100 person-years, and gradually decreased to approximately one-sixth of this rate by the 2nd year with subsequent stabilization. Multivariable analysis identified the following predictors of major GIB: anemia, estimated glomerular filtration rate <60 mL/min/1.73 m2 , and a 3-month modified Rankin Scale score of ≥4.
Conclusion:Patients with AIS are susceptible to major GIB, particularly in the first month after the onset of AIS, with the risk decreasing thereafter. Implementing preventive strategies may be important, especially for patients with anemia and impaired renal function at stroke onset and those with a disabling stroke.
