Comparative Analysis of Pregnancy Outcomes after In Vitro Fertilization with Intracytoplasmic Sperm Injection (IVF-ICSI) between Obstructive and Non-obstructive Azoospermia.
- Author:
Chan Woo PARK
;
Mi Kyoung KOONG
;
Kwang Moon YANG
;
Jin Young KIM
;
Keun Jai YOO
;
Ju Tae SEO
;
Sang Jin SONG
;
Yong Seog PARK
;
Inn Soo KANG
;
Jin Hyun JUN
- Publication Type:In Vitro ; Original Article
- Keywords:
Azoospermia;
TESE;
Fertilization rate;
Clinical pregnancy rate;
Clinical abortion rate
- MeSH:
Abnormal Karyotype;
Abortion, Induced;
Azoospermia*;
Cardiopulmonary Resuscitation;
Embryo Transfer;
Embryonic Structures;
Female;
Fertilization in Vitro*;
Humans;
Karyotype;
Oocytes;
Pregnancy;
Pregnancy Outcome*;
Pregnancy Rate;
Pregnancy*;
Sperm Injections, Intracytoplasmic*;
Sperm Retrieval;
Spermatozoa
- From:Korean Journal of Fertility and Sterility
2003;30(3):207-216
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To compare the pregnancy outcomes after in vitro fertilization with intracytoplasmic sperm injection (IVF-ICSI) between obstrucvtive and non-obstrucvtive azoospermia. METHODS: From January 1994 to December 2002, 524 patients with obstructive azoospermia (886 cycles) and 163 patients with non-obstructive azoospermia (277 cycles) were included in this study. Microsurgical epididymal sperm aspiration (MESA) or testicular sperm extraction (TESE) in obstructive azoospermia and TESE in non-obstructive azoospermia were perfomed to retrieve sperm, which was used for ICSI and then fertilized embryos were transferred. The results of ICSI-fertlization rate (FR), clinical pregnancy rate (CPR), clinical abortion rate (CAR) and delivery rate (DR)- were statistically analysed in obstructive versus non-obstructive azoospermia. RESULTS: There were no differences in the number of retrieved oocytes, injected oocytes for ICSI and oocyte maturation rate. FR was significantly higher in obstructive than non-obstructive azoospermia (71.7% vs. 61.1%, p<0.001). There was no difference in CPR per embryo transfer cycle. After pregnancy was established, however, CAR was significantly higher in non-obstructive than obstructive azoospermia (25.6% vs. 12.5%, p=0.004). DR per clinical pregnancy cycle was significantly higher in obstructive than non-obstructive azoospermia (78.0% vs. 64.4%, p=0.012). In the karyotype ananlysis of abortus, abnormal karyotypes were found in 75.0% (6/8) of obstructive and 55.6% (5/9) of non-obstructive azoospermia. CONCLUSION: Our data show significantly higher FR in obstructive than non-obstructive azoospermia. Though there was no differrence in CPR, CAR was significantly higher in non-obstructive than obstructive azoospermia. The abortion may be related to the abnormal karyotype of embryo, but further investigations are necessary to elucidate the cause of clinical abortion in azoospermia.
