Clinico-Epidemiologic study on the Abuse, Misuse, and Adverse Effects of Topical Dermatologic Drugs.
- Author:
Soo Chan KIM
1
;
Kyu Joong AHN
;
Seung Kyung HANN
;
Jin Wou KIM
;
Kyung Jeh SUNG
;
Young Chul KYE
;
Nack In KIM
;
Kwang Hyun CHO
;
Kwang Joong KIM
;
Jail Il YOUN
Author Information
1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea. kimsc@yumc.yonsei.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Topical drugs;
Abuse;
Adverse effects
- MeSH:
Acne Vulgaris;
Adrenal Cortex Hormones;
Atrophy;
Bacterial Infections;
Betamethasone Valerate;
Dermatitis, Contact;
Hospitals, University;
Humans;
Incidence;
Korea;
Nonprescription Drugs;
Pharmacists;
Prescription Drugs;
Prescriptions;
Prospective Studies;
Skin;
Substance-Related Disorders;
Telangiectasis;
Tinea;
Triamcinolone Acetonide
- From:Korean Journal of Dermatology
2003;41(9):1129-1135
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The abuse, misuse, and adverse effects to topical drugs have been widespread in Korea due to lack of awareness of seriousness of drug abuse and misuse, and improper designation of prescription and non-prescription drugs. OBJECTIVE: This study was conducted to bring Korean people to an awareness of the abuse, misuse, and adverse effects of topical drugs, and to stress the importance of proper designation of non-prescription drugs. METHODS: A multicenter, prospective, clinico-epidemiologic evaluation was made from patients with adverse effects to topical drugs who visited 31 dermatologic departments in university hospitals or private clinics nationwide from march, 2002 to December, 2002. RESULTS: The diagnostic incidence of adverse effects from topical drugs are abuse and misuse (40%), dermatophytosis incognito (29%), bacterial infection (14%), contact dermatitis (9%), acne (2.5%), skin atrophy (1.4%), telangiectasia (1%). Erghty three percent of adverse effects are caused by topical corticosteroids, and betamethasone valerate, prednicarbate and triamcinolone acetonide are commonly used topical corticosteroids that induce adverse effects frequently. The most common way to obtain topical drugs is purchase directly from pharmacist without prescriptions. CONCLUSION: From this study, we confirmed that adverse effects to topical corticosteroids are very common even after the enforcement of designation of prescription drugs and non-prescription drugs. The proper designation of prescripton drugs should be reevaluated and based on the safety of patients to protect people from adverse effects of topical drugs.
