A Clinicopathologic Study of Bowen's Disease.
- Author:
Min Su PARK
1
;
Yoon Dong KIM
;
Young June SEO
;
Jeong Hoon LEE
;
Jang Kyu PARK
Author Information
1. Department of Dermatology, Chungnam University School of Medicine, Daejeon, Korea. jhoon@hanbat.chungnam.ac.kr
- Publication Type:Original Article
- Keywords:
Bowen's disease;
Clinicopathologic study
- MeSH:
Bowen's Disease*;
Carcinoma, Squamous Cell;
Chungcheongnam-do;
Diagnosis;
Extremities;
Female;
Hand;
Humans;
Male;
Sex Ratio;
Solar System;
Ulcer
- From:Korean Journal of Dermatology
2003;41(9):1157-1162
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Bowen's disease is a form of intraepidermal (in situ) squamous cell carcinoma in histopathology, the representative premalignancy of the cutaneous squamous cell carcinoma and is usually persistent and progressive, with a small potential for invasive malignancy by 3-5%. OBJECTIVE: The purpose of this study was to investigate the clinical and histopathological characteristics of Bowen's disease. METHODS: A total of 45 patients with Bowen's disease were enrolled in this study. The hospital charts and histopathological slides were reviewed at Chungnam university hospital from 1983 to 2002. RESULTS: The male and female ratio was 1: 1.14. The mean age at diagnosis was 63 years. Twenty-two cases (58%) of solitary bowen's disease were located in non sun exposed area. Trunck, extremities, genital area followed in decreased order. Sixteen cases (42%) of solitary bowen's diseases occurred on the sun-exposed area. Face, dorsum of hand followed in decreased order. Thirty-three cases(73%) of single lesions and seven cases(27%) of multiple lesion. Analysis of clinical character of the Bowen's disease was performed and results were as follows: the most common type were patch(20 cases; 44%) and plaque (18 cases; 40%). And nodule, ulcer and papule type in decreased order. Analysis of histopathological character of the Bowen's disease was performed and results were as follows: the most common type were psoriasiform(15 cases; 41%) and irregular (12 cases; 32%). And verrucous, atrophic and combined type in decreased order. CONCLUSION: In Bowen's disease among Koreans, there were many distinctive clinical and histopathological features compared to those of non-Korean cases. In Korean cases, Bowen's diseases were located on sun exposed area only 42%, pigmented lesions were 20% and sex ratio 1: 1.14(male: female).
