Correlation between Head Circumference and Cognition in the Elderly by ApoE Genotype.
- Author:
Kyung Ran KIM
1
;
Byoung Hoon OH
;
Jun Young LEE
;
Eun A KIM
;
Hae Kwan CHEONG
;
Dong Woo LEE
;
Chang Hyung HONG
Author Information
1. Department of Psychiatry, ,Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Head circumference;
Cognition;
K-MMSE;
Elderly;
ApoE genotype;
Brain reserve
- MeSH:
Aged*;
Alcohol Drinking;
Alleles;
Apolipoproteins E*;
Cognition*;
Cognitive Reserve;
Dementia;
Genotype*;
Head*;
Humans;
Male;
Surveys and Questionnaires;
Smoke;
Smoking
- From:Journal of Korean Neuropsychiatric Association
2007;46(3):254-261
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of this study is to find out the effect of ApoE genotype on correlation between head circumference and cognition of the elderly in the community. METHODS: A total of 1,152 subjects (380 men and 772 women) aged 60-91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history and K-MMSE (Korean version-Mini Mental State Examination). We also measured the head circumference and examined ApoE genotype. RESULTS: On regression analysis, as head circumference becomes smaller, K-MMSE scores decreased adjusted by age, sex, educational level, ApoE epsilon4 allele, current smoking and alcohol drinking status (beta=0.15, p=0.04). Only in the lowest quartile group, presence of ApoE epsilon4 allele reduced K-MMSE scores adjusted by age, sex, educational level, height, current alcohol drinking and smoking status (beta=-1.39, p=0.008). CONCLUSION: These results suggest that head circumference may have an influence on K-MMSE scores, and presence of ApoE epsilon4 allele may be a medicating factor.
