Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin.
10.3347/kjp.2005.43.3.123
- Author:
Seok Joon LEE
;
Sang Tae OH
;
Gab Man PARK
;
Tong Soo KIM
;
Jae Sook RYU
;
Han Kyu CHOI
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
Plasmodium falciparum;
antimalarial activity;
artemisinin;
dihydroartemisinin;
synthesis;
natural product
- MeSH:
Animals;
Antimalarials/chemistry/*pharmacology;
Artemisinins/chemistry/*pharmacology;
Chloroquine/pharmacology;
Drug Resistance;
Plasmodium falciparum/*drug effects;
Research Support, Non-U.S. Gov't
- From:The Korean Journal of Parasitology
2005;43(3):123-126
- CountryRepublic of Korea
- Language:English
-
Abstract:
Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.
