Evaluation of pulmonary arterial stiffness in post mild COVID‑19 patients: a pilot prospective study
10.1186/s44348-024-00032-3
- Author:
Yetkin KORKMAZ
1
;
Tufan ÇINAR
;
Faysal ŞAYLIK
;
Tayyar AKBULUT
;
Murat SELÇUK
;
Mustafa OĞUZ
;
Mert Ilker HAYIROĞLU
;
İbrahim Halil TANBOĞA
Author Information
1. Department of Cardiology, Sultan II. Abdulhamid Han Training and Research Hospital, Istanbul, Türkiye
- Publication Type:RESEARCH
- From:
Journal of Cardiovascular Imaging
2024;32(1):25-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Our primary goal was to utilize pulmonary arterial stiffness (PAS) to demonstrate the early alterations in the pulmonary vascular area in individuals with prior COVID-19 illness who had not undergone hospitalization.
Methods:In total, 201 patients with prior COVID-19 infection without hospitalization and 195 healthy, age- and sexmatched individuals without a history of COVID-19 disease were included in this prospective analysis. The PAS value for each patient was calculated by dividing the mean peak pulmonary flow velocity by the pulmonary flow acceleration time.
Results:The measured PAS was 10.2 ± 4.11 Hz/msec in post–COVID-19 participants and 8.56 ± 1.47 Hz/msec in healthy subjects (P < 0.001). Moreover, pulmonary artery acceleration time was significantly lower in patients with a prior history of COVID-19. Multivariable logistic regression analysis revealed that PAS was significantly connected to a prior COVID-19 illness (odds ratio, 1.267; 95% confidence interval, 1.142–1.434; P < 0.001). The optimal cutoff point for detecting a prior COVID-19 disease for PAS was 10.1 (sensitivity, 70.2%; specificity, 87.7%).
Conclusions:This might be the first investigation to reveal that patients with a history of COVID-19 had higher PAS values compared to those without COVID-19. The results of the investigation may indicate the need of regular follow up of COVID-19 patients for the development of pulmonary arterial hypertension, especially during the post–COVID-19 interval.
