Oral administration of oxalate decarboxylase prevents hyperoxaluria and renal calcium oxalate stone formation in ethylene glycolinduced nephrolithiasis rats
10.12729/jbtr.2024.25.4.211
- Author:
Hwa Young YU
1
;
Junghyun KIM
Author Information
1. Department of Oral Pathology, School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea
- Publication Type:Original Article
- From:
Journal of Biomedical and Translational Research
2024;25(4):211-219
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hyperoxaluria is a disorder associated with an increased risk of renal stones, one of the mostcommon conditions. For people with hyperoxaluria, there are a limited number of effectivetherapeutic options. The aim of this study was to examine whether an oxalate-degrading enzyme, oxalate decarboxylase (OxdC), can inhibit crystallization of calcium oxalate (CaOx) in vitro, and whether it can prevent nephrolithiasis caused by CaOx induced by ethylene glycol (EG) in rats. When OxdC was applied at various concentrations to CaOx in vitro, there was a significant reduction in the crystallization of CaOx. The OxdC was found to inhibit crystal for-mation as well as the formation of crystals that had sharp edges. In animal experiments, ratsthat had been treated with EG showed impaired renal filtration functions, as well as increaseddeposition of CaOx crystals and the creation of kidney stones. It has been found that oral administration of OxdC to rats with chronic EG-induced nephrolithiasis that is characterized byCaOx intratubular crystal deposits with hyperoxaluria dramatically reduces the severity of thedisease. The results of this study point to a potential therapeutic approach for treating human hyperoxaluria as well as CaOx nephrolithiasis that could be achieved by the oral administra-tion of OxdC.
