The effect of ketorolac and dexamethasone on the incidence of sore throat in women after thyroidectomy: a prospective double-blinded randomized trial.
10.4097/kjae.2017.70.1.64
- Author:
Chunwoo YANG
1
;
Sung Mee JUNG
;
Yu Kyung BAE
;
Sang Jin PARK
Author Information
1. Department of Anesthesiology and Pain Medicine, Inha University School of Medicine, Incheon, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Dexamethasone;
Hoarseness;
Intubation;
Ketorolac;
Sore throat;
Thyroidectomy
- MeSH:
Administration, Intravenous;
Anesthesia;
Anesthesia, General;
Deglutition;
Dexamethasone*;
Female;
Hoarseness;
Humans;
Incidence*;
Intubation;
Intubation, Intratracheal;
Ketorolac*;
Pharyngitis*;
Prospective Studies*;
Thyroidectomy*
- From:Korean Journal of Anesthesiology
2017;70(1):64-71
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We evaluated the effect of two drugs with anti-inflammatory action, dexamethasone and ketorolac, on reduction of postoperative sore throat (POST) after general anesthesia with endotracheal intubation in patients undergoing thyroidectomy. METHODS: One hundred and ninety-two female patients scheduled to undergo general anesthesia with endotracheal intubation for thyroidectomy were enrolled in this prospective study. Participants were randomly allocated to receive intravenous medication; placebo (Group C, n = 45), ketorolac 30 mg immediately before intubation (Group Kpre, n = 47), ketorolac 30 mg at the end of surgery (Group Kpost, n = 45) and dexamethasone 10 mg (Group D, n = 43). The incidence and severity of POST and hoarseness were evaluated at 1, 6 and 24 hours after surgery. RESULTS: Incidences and severities of POST at rest and during swallowing in first 6 hours after extubation were comparable among 4 groups. At 24 hours postextubation, the incidence (P = 0.002, 95% CI of proportion differences; 0.05–0.39) and severity (P = 0.008) of POST during swallowing were significantly lower in group D than in group C. Kpre and Kpost groups did not show a greater reduction in POST than group C, despite lower rescue analgesic requirement at 1 hour after extubation in group Kpre (P = 0.006; 95% CI of proportion differences; 0.07–0.38). No intergroup differences were observed in incidences of hoarseness or adverse events. CONCLUSIONS: Intravenous administration of dexamethasone 10 mg, but not ketorolac, before induction of anesthesia reduces the incidence and severity of POST during swallowing at 24 hours after thyroidectomy.
