Korean Registry on the Current Management of Helicobacter pylori (K-Hp-Reg): Interim Analysis of Adherence to the Revised Evidence-Based Guidelines for First-Line Treatment
- Author:
Hyo-Joon YANG
1
;
Joon Sung KIM
;
Ji Yong AHN
;
Ok-Jae LEE
;
Gwang Ha KIM
;
Chang Seok BANG
;
Moo In PARK
;
Jae Yong PARK
;
Sun Moon KIM
;
Su Jin HONG
;
Joon Hyun CHO
;
Shin Hee KIM
;
Hyun Joo SONG
;
Jin Woong CHO
;
Sam Ryong JEE
;
Hyun LIM
;
Yong Hwan KWON
;
Ju Yup LEE
;
Seong Woo JEON
;
Seon-Young PARK
;
Younghee CHOE
;
Moon Kyung JOO
;
Dae-Hyun KIM
;
Jae Myung PARK
;
Beom Jin KIM
;
Jong Yeul LEE
;
Tae Hoon OH
;
Jae Gyu KIM
;
Author Information
- Publication Type:Original Article
- From:Gut and Liver 2025;19(3):364-375
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:The Korean guidelines for Helicobacter pylori treatment were revised in 2020, however, the extent of adherence to these guidelines in clinical practice remains unclear. Herein, we initiated a prospective, nationwide, multicenter registry study in 2021 to evaluate the current management of H.pylori infection in Korea.
Methods:This interim report describes the adherence to the revised guidelines and their impact on firstline eradication rates. Data on patient demographics, diagnoses, treatments, and eradication outcomes were collected using a web-based electronic case report form.
Results:A total of 7,261 patients from 66 hospitals who received first-line treatment were analyzed.The modified intention-to-treat eradication rate for first-line treatment was 81.0%, with 80.4% of the prescriptions adhering to the revised guidelines. The most commonly prescribed regimen was the 14-day clarithromycin-based triple therapy (CTT; 42.0%), followed by tailored therapy (TT; 21.2%), 7-day CTT (14.1%), and 10-day concomitant therapy (CT; 10.1%). Time-trend analysis demonstrated significant increases in guideline adherence and the use of 10-day CT and TT, along with a decrease in the use of 7-day CTT (all p<0.001). Multivariate logistic regression analysis revealed that guideline adherence was significantly associated with first-line eradication success (odds ratio, 2.03; 95% confidence interval, 1.61 to 2.56; p<0.001).
Conclusions:The revised guidelines for the treatment of H. pylori infection have been increasingly adopted in routine clinical practice in Korea, which may have contributed to improved first-line eradication rates. Notably, the 14-day CTT, 10-day CT, and TT regimens are emerging as the preferred first-line treatment options among Korean physicians.
