Hypersensitivity Reactions to Oxaliplatin.
- Author:
Kyoung Hwan LEE
1
;
Yong Jai PARK
;
Eun Sun KIM
;
Hui Jeong HWANG
;
Byoung Yong SHIM
;
Hoon Kyo KIM
Author Information
1. Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea. kimhoonkyo@ yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Hypersensitivity;
Chemotherapy;
Oxaliplatin
- MeSH:
Colorectal Neoplasms;
Drug Therapy;
Drug Therapy, Combination;
Fluorouracil;
Humans;
Hypersensitivity*;
Incidence;
Platinum
- From:Cancer Research and Treatment
2006;38(4):240-241
- CountryRepublic of Korea
- Language:English
-
Abstract:
Oxaliplatin is a third-generation platinum compound that is used as a single agent and in combination with fluorouracil (5-FU) to treat colorectal and gastric carcinoma. The patients treated with oxaliplatin may develop hypersensitivity and idiosyncratic reactions, although these complications are known to be rare. We report here on two patients who suffered with metastatic colorectal cancer and who underwent palliative combination chemotherapy with oxaliplatin; they then developed hypersensitivity reactions to oxaliplatin. The first case had an anaphylatic reaction immediately after the beginning of the 7(th) to 8(th) cycle infusion of oxaliplatin. The second case developed repeated febrile episodes from the 4th to 8th cycles of oxaliplatin infusion. With the increasing use of oxaliplatin in clinical practice, we are now encountering an increasing incidence of suspected hypersensitivity reactions. Physicians should keep their eyes wide open and carefully observe for the clinical manifestations of these hypersensitivity reactions.
