Diagnostic Efficiency of Peritoneal Fluid and Serum Lactate Dehydrogenase(LDH) in Ovarian Cancer Patients.
- Author:
Il Soo PARK
1
;
Tae Bon KOO
Author Information
1. Department Obstetrics and Gynecology, College of Medicine, Chosun University, GwangJu, Korea.
- Publication Type:Original Article
- Keywords:
ovarian cancer;
peritoneal fluid and serum LDH
- MeSH:
Ascitic Fluid*;
Biomarkers;
Diagnosis;
Endometrial Neoplasms;
Female;
Humans;
Lactic Acid*;
Leiomyoma;
Ovarian Neoplasms*;
Uterine Cervical Neoplasms
- From:Korean Journal of Gynecologic Oncology and Colposcopy
2001;12(3):217-224
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: We studied peritoneal fluid and serum LDH levels to identify patients with ovarian carcinoma and differentiate them from patients with benign ovarian tumor or other gynecological tumors. METHODS: From July 1998 to May 1999, peritoneal fluid and serum LDH, serum CA-125 levels were measured in 95 patients: 11 with ovarian carcinoma, 2 with borderline ovarian tumor, 45 with benign ovarian tumor, 2 with endometrial carcinoma, 21 with CIS, 7 with cervical cancer and 7 with uterine myoma. RESULTS: Peritoneal fluid LDH and serum LDH and CA-125 levels in ovarian cancer patients were significantly higher than those in patients with benign ovarian tumor and other gynecological tumors(p<0.05). Peritoneal fluid LDH demonstrated higher sensitivity(100%) and greater diagnostic efficiency(86%) than serum LDH(73% and 84%, respectively) or serum CA-125.(82% and 83%, respectively) CONCLUSION: Peritoneal fluid LDH, compared to serum LDH and serum CA-125, presented the greatest diagnostic efficiency in discriminating ovarian cancer from benign ovarian tumor and, therefore, it may be efficient as a biochemical marker in diagnosis of ovarian cancer, even in early stages of the disease.
