An Explorative Analysis for the Role of Serum miR-10b-3p Levels in Predicting Response to Sorafenib in Patients with Advanced Hepatocellular Carcinoma.
10.3346/jkms.2017.32.2.212
- Author:
Eileen L YOON
1
;
Jong Eun YEON
;
Eunjung KO
;
Hyun Jung LEE
;
Ji Hye JE
;
Yang Jae YOO
;
Seong Hee KANG
;
Sang Jun SUH
;
Ji Hoon KIM
;
Yeon Seok SEO
;
Hyung Joon YIM
;
Kwan Soo BYUN
Author Information
1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Serum MicroRNA;
Hepatocellular Carcinoma;
Sorafenib;
Survival;
Macrovascular Invasion
- MeSH:
Carcinoma, Hepatocellular*;
Diagnosis;
Humans;
Liver Cirrhosis;
MicroRNAs
- From:Journal of Korean Medical Science
2017;32(2):212-220
- CountryRepublic of Korea
- Language:English
-
Abstract:
The prognostic role of aberrant serum miRNA expression for predicting response to sorafenib treatment in advanced hepatocellular carcinoma (HCC) patients has not been well characterized. We aimed to identify specific serum miRNAs that are associated with positive radiologic responses or improved survival in sorafenib-treated HCC patients. miR-18a, miR-21, miR-139-5p, miR-221, miR-224, and miR-10b-3p, were selected for analysis. Serum samples from 24 patients with advanced stage HCC and 25 patients with liver cirrhosis (LC) were analyzed. All of the miRNAs except miR-21 were found to be upregulated in serum samples from HCC patients. None of the miRNAs assayed differed significantly in terms of expression between the responder and non-responder groups among HCC patients. However, miR-10b-3p levels were significantly higher in the subgroup of HCC patients with worse overall survival (fold change = 5.8, P = 0.008). Serum miRNA-10b-3p was upregulated in the presence of macrovascular invasion (MVI), and those with higher serum miRNA-10b-3p had significantly shorter survival during treatment (P = 0.042). Although no single serum miRNA was predictive of response to sorafenib treatment, analysis of serum miR-10b-3p levels may be valuable for diagnosis of HCC and prediction of survival of sorafenib-treated patients.
