Exercise Training Improves Age-Related Myocardial Metabolic Derangement: Proton Magnetic Resonance Spectroscopy Study in the Rat Model.
10.4070/kcj.2010.40.9.454
- Author:
Sang Il CHOI
1
;
Hyuk Jae CHANG
;
Eun Ju CHUN
;
Seong Bong CHO
;
Sang Tae KIM
;
Yeonyee E YOON
;
Sung A CHANG
;
Jae Hyoung KIM
;
Cheol Ho KIM
;
Tae Hwan LIM
Author Information
1. Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.
- Publication Type:Original Article
- Keywords:
Magnetic resonance spectroscopy
- MeSH:
Animals;
Creatine;
Humans;
Magnetic Resonance Spectroscopy;
Magnetics;
Magnets;
Male;
Myocardium;
Protons;
Rats;
Spectrum Analysis
- From:Korean Circulation Journal
2010;40(9):454-458
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: The objective of this study was to determine whether long-term exercise training will improve age-related cardiac metabolic derangement using proton magnetic resonance (MR) spectroscopy. MATERIALS AND METHODS: Young and old male Fischer 344 rats were assigned to sedentary controls groups {young control (YC) group-3 months of age: YC, n=10; old control (OC) group-22 months of age: OC, n=10}, and an exercise training group (OT, n=5). After 12-week of treadmill exercise training, MR spectroscopy at 4.7 T was performed to assess myocardial energy metabolism: measurements of myocardial creatine-to-water ratio (Scr/Sw) were performed using the XWIN-NMR software. RESULTS: Exercise capacity was 14.7 minutes greater in OT than that in OC (20.1+/-1.9 minutes in OT, 5.4+/-2.3 minutes in OC; p<0.001). The 12-week exercise training rendered the old rats a maximum exercise capacity matching that of untrained YC rats (17.9+/-1.5 minutes in YC, 20.1+/-1.9 minutes in OT; p>0.05). The creatine-to-water ratios in the interventricular septa of YC did not differ significantly from that of OT (0.00131+/-0.00025 vs. 0.00127+/-0.00031; p=0.37). However, OC showed significant reduction in creatine-to-water ratio compared to OT (0.00096+/-0.00025 vs. 0.00127+/-0.00031; p<0.001). Mean total creatine concentrations in the myocardium were similar between YC and OT (13.3 +/-3.6 vs. 11.5+/-4.1 mmol/kg wet weight; p=0.29). In contrast, the mean total creatine concentration of OC was significantly reduced compared to OT (6.8+/-3.2 vs. 11.5+/-4.1 mmol/kg wet weight; p=0.03). CONCLUSION: Our findings suggest that long-term exercise training in old rats induced prevention of age-related deterioration in myocardial metabolism.