Control of T-cell immunity by fatty acid metabolism
- Author:
Jaemin KIM
1
;
Yoosun LEE
;
Yeonseok CHUNG
Author Information
- Publication Type:Review Article
- From:Annals of Pediatric Endocrinology & Metabolism 2024;29(6):356-364
- CountryRepublic of Korea
- Language:English
- Abstract: Fatty acids play critical roles in maintaining the cellular functions of T cells and regulating T-cell immunity. This review synthesizes current research on the influence of fatty acids on T-cell subsets, including CD8+ T cells, TH1, TH17, Treg (regulatory T cells), and TFH (T follicular helper) cells. Fatty acids impact T cells by modulating signaling pathways, inducing metabolic changes, altering cellular structures, and regulating gene expression epigenetically. These processes affect T-cell activation, differentiation, and function, with implications for diseases such as autoimmune disease and cancer. Based on these insights, fatty acid pathways can potentially be modulated by novel therapeutics, paving the way for novel treatment approaches for immune-mediated disorders and cancer immunotherapy.
