Role of serum high-sensitive C-reactive protein to predict severity of pre-eclampsia in a high-population resource-poor country: a prospective observational study

Jhuma BISWAS; Mousumi DATTA; Kaushik KAR; Divyangana MITRA; Lakavath JYOTHI; Arghya MAITRA

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Role of serum high-sensitive C-reactive protein to predict severity of pre-eclampsia in a high-population resource-poor country: a prospective observational study

VernacularTitle:Role of serum high-sensitive C-reactive protein to predict severity of pre-eclampsia in a high-population resource-poor country: a prospective observational study
Author: Jhuma BISWAS ¹ ; Mousumi DATTA ² ; Kaushik KAR ³ ; Divyangana MITRA ⁴ ; Lakavath JYOTHI ⁵ ; Arghya MAITRA ⁶
Author Information

1. Department of Obstetrics and Gynaecology, Jhargram Government Medical College and Hospital, India
2. Department of Community Medicine, R. G. Kar Medical College and Hospital, India
3. Department of Biochemistry, Rampurhat Medical College and Hospital, India
4. Department of Obstetrics and Gynaecology, Institute of Post-Graduate Medical Education and Research (IPGMER), India
5. Department of Obstetrics and Gynaecology, Sarat Chandra Chattopadhyay Government Medical College and Hospital, India
6. Department of Obstetrics and Gynaecology, Calcutta National Medical College and Hospital, India
Keywords: pregnancy; preeclampsia; biomarkers; birth weight; high-sensitive C-reactive protein
From:Journal of Rural Medicine 2025;20(2):71-77
CountryJapan
Language:en
Abstract: Objective: To determine the role of high-sensitive C-reactive protein (hsCRP) in predicting the severity of preeclampsia in a high-population, resource-poor country.Patients and Methods: This prospective cohort study was conducted at the Department of Obstetrics and Gynaecology of Calcutta National Medical College, India, from March 2021 to September 2022. A total of 180 participants were divided into three equal groups: patients with severe preeclampsia and non-severe preeclampsia and healthy pregnant women.Results: The levels of the biomarkers hsCRP and uric acid differed significantly between women with preeclampsia and healthy women, with cutoff levels of 3.72 mg/L and 5.15mg/dL, respectively, as determined using receiver operating characteristic (ROC) curve analysis. HsCRP was also able to differentiate severe preeclampsia from non-severe preeclampsia at a cutoff level ≥8.75 mg/L (high Youden index >0.6). However, uric acid levels failed to discriminate between pregnant women with severe and non-severe preeclampsia. Elevated hsCRP levels were strongly associated with low birth weight of newborns in pregnant women with preeclampsia and healthy control groups (P=0.001) and with disease severity (P<0.001), respectively.Conclusions: HsCRP can be used as an important diagnostic tool to exclude and evaluate the severity of preeclampsia.