Malignant Hyperthermia: A Life-Threatening Condition in Patients Undergoing Surgical Intervention
- Author:
Joyti PAL
1
;
Pragya GUPTA
;
Ved Prakash MAURYA
;
Arun Kumar SRIVASTAVA
;
Devendra GUPTA
;
Luis Rafael MOSCOTE-SALAZAR
;
Tariq JANJUA
;
Amit AGRAWAL
Author Information
- Publication Type:Review Article
- From: Journal of Neurointensive Care 2024;7(2):41-48
- CountryRepublic of Korea
- Language:English
- Abstract: Malignant hyperthermia (MH) is a rare, potentially fatal genetic disorder characterized by an unexplained elevation of expired carbon dioxide despite increased minute ventilation, muscle rigidity, and rhabdomyolysis, hyperthermia, tachycardia, acidosis, and hyperkalemia. It can be triggered by many pharmacological agents such as potent inhalation agents (halothane/ isoflurane/ sevoflurane/ desflurane), the depolarizing muscle relaxant (succinylcholine), and extreme physiological conditions such as vigorous exercise and working excessively in a hot and dry environment. Prompt and early recognition of the condition and rapid initiation of treatment measures are necessary to salvage the patient. Since MH is commonly encountered in the operating room or early postoperative period, anesthetists and surgeons need to keep themselves updated regarding the same. This review article aims to summarize our understanding of MH's pathophysiology, current diagnostics, management, and treatment strategies, along with a brief review of literature of published cases in Indian Subcontinent.
