A Case of Delayed Severe Hypersensitivity Reaction during Genexol-PM(R) Infusion.
10.4046/trd.2010.68.5.294
- Author:
Hyun Kyung KIM
1
;
Su Woo KIM
;
Hye Won KANG
;
Kyoung Joo KWON
;
Hye Sung PARK
;
Yon Ju RYU
;
Jin Hwa LEE
;
Eun Mi CHUN
;
Young Joo CHO
;
Jung Hyun CHANG
Author Information
1. Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. hs1017@ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Hypersensitivity, Delayed;
Anaphylaxis;
Purpura;
Paclitaxel
- MeSH:
Aged;
Anaphylaxis;
Complement System Proteins;
Epinephrine;
Exanthema;
Humans;
Hypersensitivity;
Hypersensitivity, Delayed;
Hypotension;
Methylprednisolone;
Paclitaxel;
Purpura
- From:Tuberculosis and Respiratory Diseases
2010;68(5):294-297
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Although Taxol(R) is one of the most successful drugs in current cancer chemotherapy against solid tumors, a major problem is hypersensitivity reactions that arises as a consequence of activation of the complement (C) system, "C activation-related pseudo-allergy". Most severe hypersenstivity reactions occur within the first few minutes of Taxol(R) administration, usually after the first or second dose. Here we report a case of a severe hypersensitivity reaction in a 72-year-old man undergoing Genexol-PM(R) infusion. Hypotension and polymorphic pruritic skin rash appeared 2 hours after the start of Genexol-PM(R) infusion (with an appropriate premedication). Treating with methylprednisolone, epinephrine and inotropic agents, reduced the hypotension and the skin rash disappeared. We report this case with a review of the literature.
