Research Status and Design Ideas of Placebo Manipulation in Clinical Trial Design of Tuina
10.13288/j.11-2166/r.2025.11.008
- VernacularTitle:推拿临床试验中安慰推拿手法的现状和设计思路
- Author:
Jingui WANG
1
;
Haining ZHANG
1
;
Shun FAN
1
;
Yusheng LI
1
;
Hongyi WANG
1
;
An BAO
1
;
Wei ZHANG
1
;
Huanan LI
1
Author Information
1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion，Tianjin，300193
- Publication Type:Journal Article
- Keywords:
tuina;
placebo manipulation;
blinding;
clinical trial design
- From:
Journal of Traditional Chinese Medicine
2025;66(11):1128-1132
- CountryChina
- Language:Chinese
-
Abstract:
The rationale for the design of control groups in tuina clinical trial is the foundation for rigorously validating the effectiveness and safety of this therapy. This article reviewed the current state of the design of tuina placebo in control groups of clinical trials， pointed out the necessity of setting up tuina placebo in clinical trials of tuina， analyzed the challenges in implementing blinding of tuina manipulation， and concluded that tuina placebo is still challenged by the placebo effect， the diversification of tuina manipulation but the lack of standardization， and the difficulty of implementing blinding due to the high level of public awareness of tuina. This article also summarized the design of placebo manipulation in three types of clinical trials， including spinal manipulation， acupressure， and paediatric tuina， and proposed four strategies for designing placebo tuina manipulation-controlling placebo effects， developing operational standards for placebo tuina manipulation， ensuring the rigor of blinding implementation， and applying new technologies to enhance the standardization and blinding capacity of placebo tuina methods. So the article is aimed at improving the methodological quality of tuina clinical trial designs， and promoting the standardization and scientificity of tuina clinical trial design.
