Pathophysiological Evolution and Syndrome-Based Stratified Treatment of Qi Deficiency with Stagnation in Chemotherapy-Induced Myelosuppression
10.13288/j.11-2166/r.2025.11.005
- VernacularTitle:化疗相关骨髓抑制的虚气留滞病机演变与分度论治
- Author:
Jing LONG
1
;
Hengzhou LAI
1
;
Wenbo HUANG
1
;
Feng YU
2
;
Yifang JIANG
1
;
Zhuoling DAI
1
;
Chong XIAO
1
;
Fengming YOU
1
Author Information
1. Affiliated Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu，610075
2. Chongqing Traditional Chinese Medicine Hospital
- Publication Type:Journal Article
- Keywords:
myelosuppression;
chemotherapy;
qi deficiency with stagnation
- From:
Journal of Traditional Chinese Medicine
2025;66(11):1109-1113
- CountryChina
- Language:Chinese
-
Abstract:
The concept of "qi deficiency with stagnation" refers to a pathological state characterized by the depletion of primordial qi， impaired qi transformation， and the development of internal stagnation. Under the cyclic chemotherapy regimen in oncology， chemotherapy-induced myelosuppression follows a progressive pathological course from qi deficiency to increasing stagnation. This sequential evolution from mild to severe myelosuppression closely aligns with the dynamic syndrome differentiation and treatment framework of "qi deficiency with stagnation". "Qi deficiency" reflects the gradual depletion of qi， blood， and essence， while "stagnation" refers to the accumulation of phlegm， turbid dampness， and blood stasis. These two components interact reciprocally， forming a vicious cycle where deficiency leads to stagnation， and stagnation further damages the healthy qi. In the early stage of mild myelosuppression， chemotoxicity begins to accumulate in the bone marrow， leading to qi consumption， blood deficiency， yin injury， and the gradual formation of turbid phlegm and damp stagnation. In the advanced stage of severe myelosuppression， the accumulation of toxicity causes qi sinking， exhaustion of essence， and marrow depletion， along with blood stasis obstructing the collaterals. Treatment strategies should be based on syndrome differentiation， with an emphasis on assessing the severity of the condition， balancing deficiency and excess， and achieving both symptomatic relief and root cause resolution.
