Antiviral Effect Of Scutellaria Baicalensis Georgi
- VernacularTitle:Томуугийн Вирүсийн Эсрэг Байгал Гүүн Хөх (Scutellaria Baicalensis Georgi) Ургамлын Үзүүлэх Нөлөө
- Author:
Tserentsoo B
1
;
Oyuntsetseg N
1
;
Tserendagva D
1
;
Zorig T
1
;
Dagvatseren B
1
Author Information
1. Mongolian National University Of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Scutellaria baicalensis georgi;
antiviral effect;
plant extract
- From:
Journal of Oriental Medicine
2014;6(2):32-36
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:Influenza A viruses (IAV) are important pathogens that
cause acute diseases in humans and domestic animals. In Mongolia
only during 2010/2011 influenza season, there has been registered in
average 1232 influenza like illness per 10.000 people, which is 5.8% of
all the registered outpatient visits. Scutellaria baicalensis Georgi is one
of the most widely used Mongolian Traditional Medicine that historically
is used in anti-inflammation, anticancer, antiviral and antibacterial
therapy. The goal of this study was to study antiviral effectiveness of
Scutellaria baicalensis Georgi extract on the cells via in vitro.
Methods:Water extracts of Scutellaria baicalensis Georgi were
prepared from its rhizomes and herbs. To assess the antiviral
properties, avian influenza virus isolate A/H3/Teal/Tunka/7/2010 was
incubated at 37°C for 30min in presence and absence of plants and the
drug extracts in various concentrations. Subsequently the concentration
of infectious virus in each sample was determined by plaque assays.
Neutralisation indexes and 90% plaque reduction concentrations had
been estimated for each extract and significance of data obtained was
evaluated using convenient statisticalmethods. Results:The extracts of
Scutellaria baicalensis Georgi no significant toxicity, is well tolerated by
Madin-Darby canine kidney cells at concentrations up to 1-0.25%. The
extracts of Scutellaria baicalensis Georgi reduced the titer of
A/Teal/Tunka/7/2010 (H3N8) by 50% (p≤0.05). The plaque reduction
neutralization tests revealed that none of the extracts tested were able
to inhibit 90% of plaques. However, extract ofScutellaria baicalensis
Georgi, is able to inhibit more than 50% of plaques at low dilutions from
1:3 to 1:14 and the former two were expressing concentration-
dependent inhibitory effect. Conclusion 1.Antiviral action of the extracts
of Scutellaria baicalensis Georgiis detected. These extracts significantly
reduced the infectiveness ofinfluenza A virus H3N8 in-vitro when used
in high concentrations (1-0.25%). 2.Extract of Scutellaria baicalensis
Georgi is well tolerated by Madin-Darby canine kidney cells at
concentrations up to 0.94%.
