Alloxan Monohydrate-Аар Өдөөгдсөн Чихрийн Шижингийн Эмгэг Загварт Цульхир (Agriophyllum Pungens)-Ын Бэлдмэлийн Үзүүлэх Нөлөөг Судалсан Дүн
- VernacularTitle:Alloxan Monohydrate-Аар Өдөөгдсөн Чихрийн Шижингийн Эмгэг Загварт Цульхир (Agriophyllum Pungens)-Ын Бэлдмэлийн Үзүүлэх Нөлөөг Судалсан Дүн
- Author:
Oyunchimeg N
1
;
Ariunaa Z
1
;
Tsetsgee D
2
;
Chimedragchaa Ch
1
;
Mend-Amar B
1
Author Information
1. Health Sciences University of Mongolia
2. Health Sciences University Of Mongolia
- Publication Type:Journal Article
- Keywords:
Alloxan;
agrypum;
diabetes;
lipid profile
- From:
Journal of Oriental Medicine
2014;6(1):19-24
- CountryMongolia
- Language:Mongolian
-
Abstract:
Objective: In this study it was aimed to demonstrate the hypolipidemic and
hypoglycemic potentials of Agrypum extract on alloxan-induced diabetic rats.
Materials and methods: Eighteen male Wistar rats of weights between 140 g were
used for the study and divided into three groups of six rats each. The rats of the
non-diabetic control group were given 1 ml of distilled water daily. Two other groups
induced with diabetes using alloxan by a single dose administration of 120 mg/kg
body weight (BW); one of these diabetic rat groups were treated with seeds of this
plant (Agrypum) extract daily at 1.5 ml/100 g BW for 4 weeks while the other group
was left untreated. Blood samples were collected and total cholesterol (TC),
triglyceride (TG), high-density lipoprotein (HDL), lowdensity lipoprotein (LDL) and
glucose levels were assayed. Results: After four weeks of treatment, data indicated
significant reductions in BW, blood glucose, TG, TC and LDL levels of diabetic rats
treated with seeds of this plant (Agrypum) extract compared to the non-treated
group. The treated diabetic rats also indicated significantly higher HDL levels
compared to the non-treated group. Conclusion: Treatment of diabetic rats with the
seeds of this plant (Agrypum) extract lowered blood glucose, TG, TC and LDL levels
and increased the HDL level. This shows that the extract has both hypoglycemic
and hypolipidemic effects.
