Study Of Managchenmo Liver Protective And Bile Secretion Effects On Ccl4- Induced Hepatotoxicity
- VernacularTitle:СCI4-өөр Өдөөсөн Элэгний Хордлогот Үрэвслийн Үед Манагчэнмо Жорын Элэг Хамгаалах, Цөс Ялгаралтанд Үзүүлэх Нөлөөг Судалсан Дүн
- Author:
Zolzaya N
1
;
Alimaa T
1
;
Chimedragchaa
;
Ch
1
;
Uranzaya D
1
;
Bat-Erdene J
1
Author Information
- Publication Type:Journal Article
- Keywords: Манагчэнмо, элэг хамгаалах, цөс хөөх, элэгний хордлогот үрэвсэл, CCl4
- From: Journal of Oriental Medicine 2014;6(1):11-16
- CountryMongolia
- Language:Mongolian
- Abstract: Managchenmo is a traditional Mongolian medicine functional liquor comprising twelve crude drugs: Sus scrofa / cinis faecis /, Inula helenium L., Terminalia chebula Retz., Melia toosendan Sieb, Gardenia jasminoides Ellis, Lagotis integrifolia (Willd.)Schischk, Gentiana barbata Froel, Moschus moschiferus, Bezoar Bovis, Calcio sinteris, Carthamus tinctorius L,and Saccharum officinarum. Nowadays the Mongolian traditional herbs are more preferable than the chemical ones; for this reason studies on their use history and new technologies are conducted. Thus we study Managchinmo affects, herb for treatment of liver hot disorders, on trial rats (Handa.S.S, Sharma.A .1990 ) with hepatotoxicity. The levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkalinephosphatase (ALP) were determined through biochemical methods. The bile duct was cannulated with a tube to collect bile for two hours and bile flow was calculated by the weight of each specimen. Our results showed that Managchenmo (150 mg/kg) significantly prevented CCl4-induced changes in bile flow and serum levels of ALT, AST, and ALP. In conclusion, Managchenmo exerted a protective effect on CCl4-induced hepatotoxicity in rats.
