AntinociceptiveEffects Of The Of Deva-5 Decoction Used In Traditional Medicine In Mice
- VernacularTitle:Уламжлалт Анагаах Ухаанд Хэрэглэгддэг Дэва-5 Тангийн Туршилтын Амьтанд Үүсгэсэн Өвдөлт Намдаах Нөлөө
- Author:
Munkh-Undrakh N
1
;
Molor-Erdene P
1
Author Information
1. School of Traditional medicine MNUMS
- Publication Type:Journal Article
- Keywords:
Deva-5;
analgesia
- From:
Journal of Oriental Medicine
2013;4(1):58-63
- CountryMongolia
- Language:Mongolian
-
Abstract:
Antinociceptive effect of Deva-5 (Gentiana decumbens L.,
Terminalia Chebula Retz., Polygonium bistorta L., Momordica
cochinchinensis Lour., Chiazospermum erectum Bernh) used in
traditional medicine for treatment of infectious heat disease was
examined in both chemically- and temperature-induced pain models
of mice. Deva-5 administered orally at 100 and 200 mg/kg
significantly reduced the writhings induced by acetic acid from
control values of 37.7±6.7 (N = 6) to 24.5±3.9 (N = 6) and 18,8±2,8
(N = 6), respectively (p<0.05). When administered at 100 and 200
mg/kg, Deva-5 reduced the paw licking time for the second phase of
the formalin test from the control value of 92.6±12.9 s (N = 6) to
69.8±5.7 s (N = 6) and 70.1±11.7 s (N = 6), respectively (p<0.05).
Deva-5 had no significant effect on the first phase of the formalin
test. As evaluated by the tail immersion test, Deva-5 at doses of 100
and 200 mg/kg, showed no analgesic activity. These results show
that Deva-5 has antinociceptive activity and suggest that this effect
is probably an indirect anti-inflammatory effect, which does not
involve the central nervous system.
