Technology Of Preparing Film Coated Tablet And Gel From Cacalia Hastata L
- Author:
Jambaninj D
1
;
Davaasuren Ts
1
;
Erdenetsetseg G
1
;
Baasanjargal N
1
;
Dungerdorj D
1
Author Information
1. School of Pharmacy, Health Sciences University of Mongolia
- Publication Type:Journal Article
- Keywords:
Cacalia hastata L;
aqueous film coated tablet;
gel;
semi-solid extract;
excipients
- From:
Journal of Oriental Medicine
2012;3(2):61-62
- CountryMongolia
- Language:English
-
Abstract:
Introduction: In 2007, ” National innovation Development
Program in Mongolia” was adopted by 306th act of Mongolian
government and indicated that its important to focus attention to
research outcomes become real productions based on scientific
knowledges, experiences, skilled personnel and possibility of
laboratory and production.
In Mongolian and Tibetan traditional medicine have been used
many herbal and animal preparations has biological active
compound with anti inflammatory effect for the treatment of
wound healing and ulcer. One of them, Cacalia hastata L. is a
medicinal plant, which is widely used for the treatment of wound
healing, cholangitis and gastroduodenal ulcer in the Mongolian
and Tibetan traditional medicine.
It is appropriate to prepare film coated tablet for the treatment of
gastric and duodenal ulcer, gel for the treatment of wound
healing.
Purpose: To prepare film coated tablet for the treatment of
gastric and duodenal ulcer, gel for the treatment of wound
healing from semi-solid extract of Cacalia hastata L. and
determine their quality criteria.
Material and methods: Herb of Cacalia hastata L. was collected
as a raw material from Terelj in July 2009; from Batsumber
soum, Tuv aimag province in July 2010, 2011. For determining
of quality of semi-solid extract and new drug formulations were
evaluated biological activity compounds such as alkaloid,
carotenoid and flavonoid by spectrophotometric method. We
prepared film coated tablet by wet granulation and film coating
method and gel by dispersion method.
Tests for significant differences between means were performed
by one sample t-test and One way ANOVA using the software
SPSS 16. Differences were considered significant at p<0.05.
Results: We prepared tablet from semi-solid extract of Cacalia
hastata L. For preparing the film coated tablet used mixture
solution of 8 % gelatin and 6 % sodium carboxymethylcellulose
as a binder, sodium carbonate as diluents. The tablet was
coated 5% solution of hydroxypropylmethylcellulose with 10 %
polyethyleneglycol as a film former used traditional coating pan.
Film coated tablet was standardized by such criteria, as
appearance (colour, smell), the average weight, amount of
biologically active compound, hardness, disintegration,
dissolution and bacterial contamination. We prepared Cacalia
gel from semi-solid extract of Cacalia hastata L. using various
excipients and determined quality criteria, developed
technological scheme of preparing. Gel was standardized by
such as criteria: appearance (color, smell), the amount of
biologically active compound, pH, viscosity, spreadability,
extrudability and bacterial contamination.
Conclusions: 1. Developed technology of preparing 0.3 gram film
coated tablet from semi-solid extract of Cacalia hastata L. and
determined quality criteria. 2. Developed technology of gel from
semi-solid extract of Cacalia hastata L. and standardized its
quality.
