Study Of Some Traditional Drugs Based On Calcite Processed  By Traditional Technology

Seesregdorj S; Molor-Erdene P; Ariunjargal N; Dorjbat S; Soyolt S; Tsendjav D

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Study Of Some Traditional Drugs Based On Calcite Processed By Traditional Technology

Author: Seesregdorj S ¹ ; Molor-Erdene P ¹ ; Ariunjargal N ¹ ; Dorjbat S ¹ ; Soyolt S ¹ ; Tsendjav D ¹
Author Information

1. School of Traditional Medicine, Health Sciences University of Mongolia
Publication Type:Journal Article
Keywords: Calcite; macro-and microelements
From: Journal of Oriental Medicine 2012;3(2):59-59
CountryMongolia
Language:English
Abstract: In traditional Mongolian Medicine, materials derived from plants, animals, trees, and minerals are processed by traditional technology to improve their effectiveness and safety. One of mineral-based materials is calcite which is widely used in traditional medicine. Mineral contents of calcite: After processing by traditional technology (taming) with enrichment, calcite turns to bright yellow, small soft microcrystals with bitter taste and smell of milk. Moreover it obtains solubility in water. Various macro- and microelements were determined in tamed calcite including Na, Mg, K, Ca, S, Mn, and Fe. Ca takes the major part (64%) of the elements. Crystal size determined by NANOPHOX (PCCS), GmbH, Sympatec apparatus were 115 nm and 124 nm depending on the traditional technology of processing. Crystal structure of calcite in phase shifts was analyzed after burning it in +300º C, +500 º C, +800 º C, +1200 º C, and +1400 º C by using Shimadzu XRD-7000 X-ray diffractometer, HA- 1001, and TTK-450 apparatus. CaCO3 content (84.23%) was higher at +300º C and +500 º C, while CaC2 content (15.77%) was higher at +800 º C, +1200 º C, and +1400 ºC. Effects of calcite on acetic acid-induced gastric ulcer: Gastric ulcer induced by acetic acid in rats was healed completely by tamed calcite within 21 days. Calcite improves bone repair of experimental fracture in rats by increasing Ca and alkaline phosphatase activities. Effects of calcite containing drug Jonsh-5 on experimental femur fracture in rabbits: Jonsh-5 is composed of 5 components including calcite, Cardius crispus, Forsythia suspense, Terminalia Chebula, and Inula helenium. Jonsh-5 increased serum level of alkaline phosphatase after 7 days of fracture. X- ray images showed that healing process of the bone was significantly increased by Jonsh-5 compare to control and Calcium D3-Nycomed treatment. These results were also proved by histological analysis suggesting that Jonsh-5 may promote bone healing in rat model of fracture. Safety of calcite containing drugs: Contents of macro- and microelements, moisture, and substances extractable in water have been determined. Mineral and organic impurities have also been evaluated in Jonsh-5. Bacterial impurity of the drug is within the standard range. Moreover contents of heavy metals such as lead, cadmium, and mercury meat the WHO permeated levels of toxic metals.