Pharmacological Studies Of Traditional Drug Garid-5
- Author:
Uuganbayar B
1
;
Ariunaa Z
1
;
Chimedragchaa Ch
1
;
Oldokh S
1
;
Nasensang J
1
Author Information
1. Traditional Medical Science Technology and Production Corporation of Mongolia
- Publication Type:Journal Article
- Keywords:
Analgesic effect
- From:
Journal of Oriental Medicine
2012;3(2):37-37
- CountryMongolia
- Language:English
-
Abstract:
Objectives: Aim of this study is to define peripheral analgesic
effect of the traditional drug Garid-5 in mice.
Methods: Garidi-5 produced in drug manufacture of Traditional
Medical Science, Technology and Production Corporation of
Mongolia was used for the study.
All animals used in this study were taken care of under ethical
consideration, with approval from Ethical Committee Corporation
and Minister of Health of Mongolia. LD50 of Garidi-5 was
determined by Chan Chi’s method. Mice of either sex weighing
20-30 g were fasted overnight and divided into three groups with
six animals in each group. One hour after administration of
drugs, induction of writhing was done in mice by giving intra
peritoneal injection of acetic acid at a dose of 10 ml/kg body
weight. The number of writhing responses were counted and
recorded for 20 min. Garid-5 was given to mice at doses of 20
mg/kg, 80 mg/kg, and 200 mg/kg. Aspirin (100 mg/kg) was used
as a standard drug.
Results: The median lethal dose (LD50) of Garid-5 was found to
be 2.28 g/kg. Aqueous extract of Gardi-5 reduced pain from 40.4
% to 47.9% in mice administered acetic acid compare to control
mice (p<0.05).
Conclusion: Garid-5 is safe in mice demonstrating no noticeable
toxicity. Garid-5 exhibits a potent peripheral analgesic effect.
